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Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes showed that patients had the average weight loss of four.1% in contrast to participants have been given placebos) within a 12- month period, while another study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at twelve months. Using two separate drugs to lose weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err on the side of caution and allow the FDA do its job and demand some investigation be done so that the public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies come in business to generate money and that they would say almost anything to keep people on their own medications. Researchers discovered that participants investing in this drug for the year, dropped excess weight within four weeks and have kept the load off through the 56 weeks in the study. Contrave is a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them more potent and safer. Combo-pilling is the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular could be the fact that as of right now there are not any long term prescription slimming capsules that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug also can raise blood pressure level and pulse rate, and really should not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients for the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. Please show your support by clicking the 'Like', 'Subscribe' and 'Share' buttons found on this page.